Proteolipid Protein 1 (PLP1): A Comprehensive Research Review for Neuroscience and Myelin Biology Researchers
Introduction to PLP1 Protein Proteolipid Protein 1 (PLP1) is the most abundant integral membrane protein in central nervous system (CNS) myelin, constituting approximately 50% of the total myelin protein content. This highly hydrophobic protein, encoded by the PLP1 gene located on the X chromosome (Xq22.2), plays a fundamental role in myelin formation, stabilization, and maintenance. …
